Glyoxylate dehydrogenase (acylating)

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In enzymology, a glyoxylate dehydrogenase (acylating) (EC 1.2.1.17) is an enzyme that catalyzes the chemical reaction

glyoxylate + CoA + NADP⁺ oxalyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are glyoxylate, CoA, and NADP⁺, whereas its 3 products are oxalyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glyoxylate:NADP+ oxidoreductase (CoA-oxalylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 1.2.1.17
• BRENDA references for 1.2.1.17 (Recommended.)
• PubMed references for 1.2.1.17
• PubMed Central references for 1.2.1.17
• Google Scholar references for 1.2.1.17
• Quayle JR and Taylor GA (1961). "Carbon assimilation by Pseudomonas oxalaticus (OX1). 5. Purification and properties of glyoxylic dehydrogenase". Biochem. J. 78: 611–615. 

[edit] External links

The CAS registry number for this enzyme class is 9028-96-0.

• IUBMB entry for 1.2.1.17

• KEGG entry for 1.2.1.17

• BRENDA entry for 1.2.1.17

• NiceZyme view of 1.2.1.17

• EC2PDB: PDB structures for 1.2.1.17

• PRIAM entry for 1.2.1.17

• PUMA2 entry for 1.2.1.17

• IntEnz: Integrated Enzyme entry for 1.2.1.17

• MetaCyc entry for 1.2.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047968: glyoxylate dehydrogenase (acylating)

• AMIGO entry for GO code 0047968: glyoxylate dehydrogenase (acylating)