Glycerol 3-phosphate
From Wikipedia, the free encyclopedia
| Glycerol 3-phosphate | |
|---|---|
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| IUPAC name | 1,2,3-Propanetriol, 1- (dihydrogen phosphate) |
| Other names | Glycerol-1-phosphate Glycerophosphate α-glycerolphosphate |
| Identifiers | |
| CAS number | [57-03-4] |
| PubChem | |
| MeSH | |
| SMILES | OCC(O)COP(O)(O)=O |
| Properties | |
| Molecular formula | C3H9O6P |
| Molar mass | 172.074 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Glycerol 3-phosphate is a chemical intermediate in the glycolysis metabolic pathway. It should not be confused with the similarly named glycerate 3-phosphate or glyceraldehyde 3-phosphate.
[edit] Function
Glycerol 3-phosphate is produced from glycerol, the triose sugar backbone of triglycerides and glycerophospholipids, by the enzyme glycerol kinase. Glycerol 3-phospate may then be converted by dehydrogenation to dihydroxyacetone phosphate (DHAP) by the enzyme glycerol-3-phosphate dehydrogenase. DHAP can then be rearranged into glyceraldehyde 3-phosphate(GA3P) by triose phosphate isomerase(TIM), and feed into glycolysis.
The glycerol 3-phosphate shuttle is used to rapidly regenerate NAD+ in brain and skeletal muscle cells of mammals.
