Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

From Wikipedia, the free encyclopedia

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) (EC 1.2.1.13) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NADP⁺ 3-phospho-D-glyceroyl phosphate + NADPH + H⁺

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP⁺, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase (NADP+), dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), glyceraldehyde phosphate dehydrogenase (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), NADP+-glyceraldehyde-3-phosphate dehydrogenase, NADP+-glyceraldehyde phosphate dehydrogenase, NADP+-dependent glyceraldehyde phosphate dehydrogenase, NADP+-triose phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), and GAPDH. This enzyme participates in carbon fixation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1JN0, 1NBO, 1RM3, 1RM4, 1RM5, 2D2I, 2DUU, 2HKI, 2PKQ, and 2PKR.

[edit] References

• IUBMB entry for 1.2.1.13
• BRENDA references for 1.2.1.13 (Recommended.)
• PubMed references for 1.2.1.13
• PubMed Central references for 1.2.1.13
• Google Scholar references for 1.2.1.13
• BRENNEMAN FN, VOLK WA (1959). "Glyceraldehyde phosphate dehydrogenase activity with triphosphopyridine nucleotide and with diphosphopyridine nucleotide". J. Biol. Chem. 234: 2443–7. PMID 13804190. 
• Gibbs M (1955). "TPN triosephosphate dehydrogenase from plant tissue". Methods Enzymol. 1: 411–415. 
• ROSENBERG LL, ARNON DI (1955). "The preparation and properties of a new glyceraldehyde-3-phosphate dehydrogenase from photosynthetic tissues". J. Biol. Chem. 217: 361–71. PMID 13271400. 

[edit] External links

The CAS registry number for this enzyme class is 37250-87-6.

• IUBMB entry for 1.2.1.13

• KEGG entry for 1.2.1.13

• BRENDA entry for 1.2.1.13

• NiceZyme view of 1.2.1.13

• EC2PDB: PDB structures for 1.2.1.13

• PRIAM entry for 1.2.1.13

• PUMA2 entry for 1.2.1.13

• IntEnz: Integrated Enzyme entry for 1.2.1.13

• MetaCyc entry for 1.2.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047100: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

• AMIGO entry for GO code 0047100: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)