Talk:Glutamate decarboxylase
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The following text on L-Glutamic acid decarboxylase was replaced with a redirect to this article:
L-Glutamic acid decarboxylase (GAD) (EC 4.1.1.15) is an enzyme necessary for the synthesis of the inhibitory neurotransmitter GABA in GABAergic nerve endings. In the presence of pyridoxal phosphate as cofactor, the enzyme decarboxylates glutamate to yield GABA and CO2. GAD exists in two isoforms encoded by two different genes. These isoforms are GAD65 and GAD67 with molecular weights of 65 and 67 kDa, respectively. GAD67 is only present in GABAergic neurons and so can be used as a marker.
In experimental animals, administration of drugs to inhibit GAD invariably leads to epileptic seizures. People with diabetes mellitus type 1 often have autoantibodies against GAD65, leading to speculation about the role these antibodies play in the development of diabetes mellitus.[1]
[edit] GAD transfer gene therapy for Parkinson's
Interesting theme, could be investigated and some info added in the article. (PMID 11529246, PMID 17586305; also some media articles). CopperKettle 12:14, 5 July 2007 (UTC)
