Talk:Glucose-6-phosphate dehydrogenase deficiency

From Wikipedia, the free encyclopedia

WikiProject Medicine This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
B This page has been rated as B-Class on the quality assessment scale
Low This article has been rated as Low-importance on the importance assessment scale


Contents

[edit] I

I moved this from "Glucose-6-Phosphate Dehydrogenase deficiency"; the capitals were making it hard to find the page. It was an attempt to seperate the name of the enzyme affected from the deficiency, but IMHO that's contrary to policy. JFW | T@lk 09:57, 27 Apr 2004 (UTC)

[edit] Hemolysis in DKA

I found conflicting reports as to haemolysis in the context of DKA. PMID 8887143 seems to suggest it is the drop in glucose that precipitates the haemolysis. PMID 4623682 suggests the DKA caused the haemolysis. There is actually very little published literature on the subject. JFW | T@lk 17:36, 23 March 2006 (UTC)

[edit] epid

thalasemias could also be added in their relationship to preventing malaria. and linked.

This page is pretty useless to readers without a background in medicine, and thus as a general information encyclopedia article. Recommend a summary be written in lay-english, without all the medical jargon.

[edit] DRUGS AND FOODSTUFF TO AVOID FOR PERSONS WITH LACK OF G6PD (FAVISM)

It is vital for the people with the FIVISM (G6PD Deficient) persons to know that they should avoid some drugs, chemicals and foodstuffs. The list of the DRUGS AND FOODSTUFF TO AVOID for the G6PD deficient (FAVISM) persons are stated in the "G6PD Deficiency - FAVISM Association" at the following link: link title

There is already a link to g6pd.org - Wikipedia has no duty in warning people against foods or drugs. That is the job of their healthcare provider. JFW | T@lk 19:48, 28 October 2007 (UTC)

[edit] Favism?

An anonymous editor from the 70.108 range has now twice left the following note in the article:

This page needs to be edited. Favism is a medical disorder, resulting from eating broad beans. G6PD deficient is a biochemical imbalance. They are often linked but not always. For instance see here: http://www.kfshrc.edu.sa/annals/166/95-371.html This article needs to be edited to reflect this, and Favism should have its own separate article.

I don't find the URL provided very informative. As far as I can gather (and support with the Mehta reference), favism is the syndrome that develops when people with marked erythrocyte G6PD deficiency consume beans with high levels of vicine, divicine, convicine and isouramil. People with normal or low-normal G6PD levels do not develop this syndrome - I have never heard of favism in a patient with normal G6PD levels. Furthermore, Wikipedia articles occasionally cover multiple related topics in one article when it is thought this makes things easier to explain. JFW | T@lk 19:48, 28 October 2007 (UTC)

Sorry for the guerilla editing, but there seems to be a big problem with commonly equating G6PD with favism when this is simply not the case. G6PD deficieny is much more common than favism, and equating the two is being needlessly alarmist. The Al-Ali article (HTML version) is only used as a specific example, not a authoritative reference. It describes a small study of over 757 Saudi men. Over 42% of them tested positive for G6PD deficiency, but none of them reported symptoms of favism. The abstract of the Mehta review states, "Although most affected individuals are asymptomatic," indicating clearly that most G6PD deficient individuals do not show favism. The Beutler review states the relationship between favism and G6PD deficiency clearly, "Patients with favism are always G6PD deficient, but not all G6PD-deficient individuals develop hemolysis when they ingest fava beans. Thus, G6PD deficiency is a necessary but not sufficient cause of favism. Presumably some other factor, probably also genetic and very likely related to metabolism of the active ingredients in the beans, is involved." It is reasonable that this one Wikipedia article should treat both G6PD and favism, but it should be clear about the difference, rather than simply equating the two. I understand that "best practice" might be to err on the side of caution and presume that a patient presenting with G6PD also has favism, and I think the wikipedia article has an obligation to state this advice (perhaps in a separate "best practices" section). However, the article should also give the facts, up front, that among individuals who test positive for G6PD deficiency, the precise odds for having favism or other specific food/drug sensitivities are mostly unknown. For the general case of sensitivity to fava beans (favism), the odds are known to be low. Factors that might affect these odds include G6PD variant and age. —Preceding unsigned comment added by 70.108.59.224 (talk) 01:41, 29 October 2007 (UTC)

That's not guerilla editing, especially now you have simply made the correction you thought was necessary. Still, if you were a haematologist treating G6PD, would you allow people with mild deficiency to eat broad beans? I think one would still be erring on the side of caution. JFW | T@lk 06:33, 29 October 2007 (UTC)

[edit] Beutler

On the occasion of the ASH fiftieth anniversary, Ernest Beutler has again reviewed G6PD deficiency: doi:10.1182/blood-2007-04-077412 10.1182/blood-2007-04-077412 JFW | T@lk 16:27, 23 December 2007 (UTC)