Glutamate-5-semialdehyde dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) is an enzyme that catalyzes the chemical reaction
- L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
The 3 substrates of this enzyme are L-glutamate 5-semialdehyde, phosphate, and NADP+, whereas its 3 products are L-glutamyl 5-phosphate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating). Other names in common use include beta-glutamylphosphate reductase, gamma-glutamyl phosphate reductase, beta-glutamylphosphate reductase, glutamate semialdehyde dehydrogenase, and glutamate-gamma-semialdehyde dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.
Contents |
[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1O20, 1VLU, and 2H5G.
[edit] References
- IUBMB entry for 1.2.1.41
- BRENDA references for 1.2.1.41 (Recommended.)
- PubMed references for 1.2.1.41
- PubMed Central references for 1.2.1.41
- Google Scholar references for 1.2.1.41
- Baich A (1971). "The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway". Biochim. Biophys. Acta. 244: 129–34. PMID 4399189.
[edit] External links
-
- The CAS registry number for this enzyme class is 54596-29-1.
[edit] Gene Ontology (GO) codes
 |
This EC 1.2 enzyme-related article is a stub. You can help Wikipedia by expanding it. |
