Glucosidases
From Wikipedia, the free encyclopedia
Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.
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[edit] Function
α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen
They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.
[edit] Members
Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.
| Name | EC | Description |
| α-Amylase | EC 3.2.1.1 | is a digestive enzyme in mammals |
| β-Amylase | EC 3.2.1.2 | is a plant enzyme to break down starch |
| γ-Amylase | EC 3.2.1.3 | is a digestive enzyme |
| Cellulase # | EC 3.2.1.4 | breaks down cellulose from plant material |
| Sucrase-isomaltase | EC 3.2.1.10 | - |
| Acid α-glucosidase # | EC 3.2.1.20 | is associated with Glycogen storage disease type II |
| Beta-glucosidase # | EC 3.2.1.21 | - is associated with gaucher's disease |
| Lactase | EC 3.2.1.23 | one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance |
| Debranching enzyme # | EC 3.2.1.33 | - |
| Pullulanase | EC 3.2.1.41 | has been used as a detergent |
[edit] Clinical significance
They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.
[edit] See also
[edit] External links
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