Gluconate 2-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a gluconate 2-dehydrogenase (EC 1.1.1.215) is an enzyme that catalyzes the chemical reaction

D-gluconate + NADP⁺ 2-dehydro-D-gluconate + NADPH + H⁺

Thus, the two substrates of this enzyme are D-gluconate and NADP⁺, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP+ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.

[edit] References

• IUBMB entry for 1.1.1.215
• BRENDA references for 1.1.1.215 (Recommended.)
• PubMed references for 1.1.1.215
• PubMed Central references for 1.1.1.215
• Google Scholar references for 1.1.1.215
• Ameyama M (1978). "Crystalline 2-ketogluconate reductase from Acetobacter ascendens, the second instance of crystalline enzyme in genus Acetobacter". Agric. Biol. Chem. 42: 2057. 
• Chiyonobu T, Shinagawa E, Adachi O and Ameyama M (1976). "Purification, crystallization and properties of 2-ketogluconate reductase from Acetobacter rancens". Agric. Biol. Chem. 40: 175–184. 

[edit] External links

The CAS registry number for this enzyme class is 68417-42-5.

• IUBMB entry for 1.1.1.215

• KEGG entry for 1.1.1.215

• BRENDA entry for 1.1.1.215

• NiceZyme view of 1.1.1.215

• EC2PDB: PDB structures for 1.1.1.215

• PRIAM entry for 1.1.1.215

• PUMA2 entry for 1.1.1.215

• IntEnz: Integrated Enzyme entry for 1.1.1.215

• MetaCyc entry for 1.1.1.215

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008873: gluconate 2-dehydrogenase

• AMIGO entry for GO code 0008873: gluconate 2-dehydrogenase