Talk:Giant cell tumor of bone

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[edit] Giant

Giant cell tumors, aneurysmal bone cysts, and Brown tumors/osteoclastomas are not the same thing. Giant cell tumors arise from the monocyte/macrophage system and have telomeric associations (end to end fusion chromosomes). These occur in skeletally mature young adults. Aneurysmal bone cysts are similar, but they are more of a reactive bone formation that happen to have giant cells. These occur primarily in adolescents. Osteoclastomas, while similar in appearance, are all alltogether different in terms of pathogenesis. These lesions are the complication of long standing hyperparathyroidism. Increased levels of parathyroid hormone stimulate osteoclasts to degrade bone in order to increase serum Calcium levels.

I am aware that these two tumors are not the same thing, but they are often together when a patient is diagnosed. Please leave me some feedback on my talk page and we can get this article cleaned up.

Bearingbreaker92 | Talk 12:13, 20 December 2006 (UTC)