Gamma-guanidinobutyraldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a gamma-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) is an enzyme that catalyzes the chemical reaction

4-guanidinobutanal + NAD⁺ + H₂O 4-guanidinobutanoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-guanidinobutanal, NAD⁺, and H₂O, whereas its 3 products are 4-guanidinobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-guanidinobutanal:NAD+ 1-oxidoreductase. Other names in common use include alpha-guanidinobutyraldehyde dehydrogenase, 4-guanidinobutyraldehyde dehydrogenase, and GBAL dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.

[edit] References

• IUBMB entry for 1.2.1.54
• BRENDA references for 1.2.1.54 (Recommended.)
• PubMed references for 1.2.1.54
• PubMed Central references for 1.2.1.54
• Google Scholar references for 1.2.1.54
• Yorifuji T, Koike K, Sakurai T and Yokoyama K (1986). "4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida". Agric. Biol. Chem. 50: 2009–2016. 

[edit] External links

The CAS registry number for this enzyme class is 56831-75-5.

• IUBMB entry for 1.2.1.54

• KEGG entry for 1.2.1.54

• BRENDA entry for 1.2.1.54

• NiceZyme view of 1.2.1.54

• EC2PDB: PDB structures for 1.2.1.54

• PRIAM entry for 1.2.1.54

• PUMA2 entry for 1.2.1.54

• IntEnz: Integrated Enzyme entry for 1.2.1.54

• MetaCyc entry for 1.2.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047107: gamma-guanidinobutyraldehyde dehydrogenase

• AMIGO entry for GO code 0047107: gamma-guanidinobutyraldehyde dehydrogenase