Galactoside 2-alpha-L-fucosyltransferase

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In enzymology, a galactoside 2-alpha-L-fucosyltransferase (EC 2.4.1.69) is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + beta-D-galactosyl-R $\rightleftharpoons$ GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase. Other names in common use include blood group H alpha-2-fucosyltransferase, guanosine diphosphofucose-galactoside 2-L-fucosyltransferase, alpha-(1->2)-L-fucosyltransferase, alpha-2-fucosyltransferase, alpha-2-L-fucosyltransferase, blood-group substance H-dependent fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase, guanosine diphosphofucose-lactose fucosyltransferase, GDP fucose-lactose fucosyltransferase, guanosine diphospho-L-fucose-lactose fucosyltransferase, guanosine, diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase, guanosine, diphosphofucose-, galactosylacetylglucosaminylgalactosylglucosylceramide, alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase, H-gene-encoded beta-galactoside alpha1->2fucosyltransferase, secretor-type beta-galactoside alpha1->2fucosyltransferase, beta-galactoside alpha1->2fucosyltransferase, and GDP-L-fucose:lactose fucosyltransferase. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

[edit] References

IUBMB entry for 2.4.1.69
BRENDA references for 2.4.1.69 (Recommended.)
PubMed references for 2.4.1.69
PubMed Central references for 2.4.1.69
Google Scholar references for 2.4.1.69
Basu S, Basu M, Chien JL (1975). "Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen". J. Biol. Chem. 250: 2956–62. PMID 804484.
Beyer TA, Hill RL (1980). "Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255: 5373–9. PMID 7372640.
Beyer TA, Sadler JE, Hill RL (1980). "Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255: 5364–72. PMID 6246105.
Grollman AP (1966). "GDP-L-fucose:lactose fucosyltransferase from mammary gland". Methods Enzymol. 8: 351–353.