Fructose 5-dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a fructose 5-dehydrogenase (NADP+) (EC 1.1.1.124) is an enzyme that catalyzes the chemical reaction

D-fructose + NADP⁺ $\rightleftharpoons$ 5-dehydro-D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are D-fructose and NADP⁺, whereas its 3 products are 5-dehydro-D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-fructose:NADP+ 5-oxidoreductase. Other names in common use include 5-ketofructose reductase (NADP+), 5-keto-D-fructose reductase (NADP+), fructose 5-(nicotinamide adenine dinucleotide phosphate), dehydrogenase, D-(-)fructose:(NADP+) 5-oxidoreductase, and fructose 5-dehydrogenase (NADP+).

[edit] References

IUBMB entry for 1.1.1.124
BRENDA references for 1.1.1.124 (Recommended.)
PubMed references for 1.1.1.124
PubMed Central references for 1.1.1.124
Google Scholar references for 1.1.1.124
Ameyama M, Matsushita K, Shinagawa E and Adachi O (1981). "5-keto-D-Fructose reductase of Gluconobacter industrius Purification, crystallization and properties". Agric. Biol. Chem. 45: 863–869.
Avigad G, Englard S, Pifko S (1966). "5-Keto-D-fructose. IV. A specific reduced nicotinamide adenine dinucleotide phosphate-linked reductase from Gluconobacter cerinus". J. Biol. Chem. 241: 373–8. PMID 4379259.