Fructose 2,6-bisphosphatase

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Fructose-2,6-bisphosphatase is an enzyme that catalyzes the following reaction:

fructose-2,6-bisphosphate + H2O ---> fructose-6-phosphate + phosphate ion

Fructose 2,6-bisphosphate

Fructose 6-phosphate

Fructose-2,6-bisphosphatase is important in regulation of gluconeogenesis & glycolysis as it catalyzes the dephosphorylation of fructose-2,6-bisphosphate. Because fructose-2,6-bisphosphate activates phosphofructokinase-1 (a critical enzyme in glycolysis) and inhibits fructose-1,6-bisphosphatase (a critical enzyme in gluconeogenesis), the activity of fructose-2,6-bisphosphatase decreases glycolysis and increases gluconeogenesis.

Fructose-2,6-bisphosphatase is subject to product inhibition by fructose-6-phosphate. Fructose-2,6-bisphosphatase also undergoes addition of a phosphate group to a single serine residue by cAMP-dependent protein kinase (known as covalent modification), which activates (increases catalytic activity) of Fructose-2,6-bisphosphatase.

[edit] See also

• Phosphofructokinase 2

[edit] External links

• MeSH Fructose+2,6-bisphosphatase
• EC 3.1.3.46
• PFKFB1, PFKFB2

v • d • e Hydrolase: esterases (EC 3.1) 3.1.1: Carboxylic ester hydrolases Cholinesterase - Pectinesterase - 6-phosphogluconolactonase - PAF acetylhydrolase Lipase (Gastric/Lingual, Pancreatic, Lysosomal, Hormone-sensitive, Endothelial, Hepatic, Lipoprotein, Monoacylglycerol, Diacylglycerol) Phospholipase (A1, A2, B) 3.1.2: Thioesterase Palmitoyl thioesterase - Ubiquitin carboxy-terminal hydrolase L1 3.1.3: Phosphatase Alkaline phosphatase - Acid phosphatase (Prostatic)/Tartrate resistant acid phosphatase/Purple acid phosphatases - Nucleotidase - Glucose 6-phosphatase - Fructose 1,6-bisphosphatase - Calcineurin - Phosphoprotein phosphatase (PP2A) - OCRL - Pyruvate dehydrogenase phosphatase - Fructose 2,6-bisphosphatase - Protein tyrosine phosphatase - PTEN 3.1.4: Phosphodiesterase Autotaxin - Phospholipase (C, D) - Sphingomyelin phosphodiesterase - PDE1 - PDE2 - PDE3 - PDE5 3.1.6: Sulfatase Arylsulfatase B - Steroid sulfatase - Galactosamine-6 sulfatase - Arylsulfatase A - Iduronate-2-sulfatase - N-acetylglucosamine-6-sulfatase other Nuclease

v • d • e Metabolism: carbohydrate metabolism: glycolysis/gluconeogenesis enzymes Glycolysis Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase Aldolase - Triosephosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase Gluconeogenesis only to oxaloacetate: Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase from lactate (Cori cycle): Lactate dehydrogenase from alanine (Alanine cycle): Alanine transaminase from glycerol: Glycerol kinase - Glycerol dehydrogenase Regulatory Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase see also disorders