Talk:Estrogen
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[edit] Estrogen Production
Is it just me, or does it look weird to have this section start with a sentence about the production of testosterone, the major androgen? The human body can and does aromatize testosterone to estardiol, but this is not the major pathway for production in females. Any objections to deleting this sentence? Pustelnik (talk) 01:13, 5 January 2008 (UTC)
Also, shouldn't the production of estrone in peripheral adipose tissue be mentioned as a site of synthesis?Peetiemd (talk) 11:48, 7 May 2008 (UTC)
[edit] Could
Could you back up that claim of controversiality of HRT to treat menopause symptoms? AFAIK it is pretty much standard by now.
Anyway, that note should probably be moved to the HRT article. -- Kimiko 20:36, 6 Sep 2003 (UTC)
[edit] HRT pros and cons
I think HRT after menopause still has the increased risk of osteoporosis. However, I think I've read somewhere that it reduces the occurence of cardiovascular diseases. Correct me if I'm wrong on that. AttishOculus 08:26, 25 Apr 2005 (UTC)
[edit] Additions
This article could use some expansion, such as chemical formulas, pictures, specifics in regulating menstrual cycle, etc. I will have time within a few days to do so. -- Bubbachuck 18:56, 18 August 2005 (UTC)
- I was looking for disorders involving estrogen --geekyßroad 09:24, 30 January 2006 (UTC)
[edit] Both sides
Estrogen do have certain side effects. I guess we should provide wholesome info. Jagdishh (talk · contribs)
- What, to the physiological hormone, or to synthetic/exogenous administration? JFW | T@lk 21:29, 12 November 2005 (UTC)
[edit] Estrogens in non-humans
This article is very much incomplete since it limited to estrogens in humans. A broader biological context should be included. Do animals use estrogens different than humans do. And what about estrogens in plants? Articles on biological structures and chemicals should whenever possible address fuction and structure outside of one or a few species. Any that does not is incomplete. Regrettably, I don't know enough about the subject to really contribute on this other than to point out that non-human life has estrogens as well. I am quite sure that soy plants are not using estrogen for breast enlargment. ;-) So what are they using it for? This really needs to be addressed. After all the article is "Estrogen" and not "Estrogen in humans". MichaelSH 16:01, 19 February 2006 (UTC)
- Actually, you'd be surprised. Soy plant contain Phytoestrogens (roughly meaning plant estrogen) that are compounds that have an ability to bind to human estrogen sites, thus mimicking the hormone estrogen. In some people it could actually perform like estrogen, and could promote feminization, although in others it can act as an estrogen inhibiting agent, as phytoestrogens are generally very weak estrogen-like compounds, and only so much of hormones will actually react, so that if the estrogen binding sites are overloaded (either with excessive estrogens, or phytoestrogens) then only a part of each will bind to the sight, thus (this is grossly simplified) let us say that some particular phytoestrogen has half the effectiveness of natural estrogen, and say Subject XY has 10% saturation of estrogen binding sites with natural estrogen, and they consume sufficient phytoestrogens to have 50% of the binding sites bound, then they would have 35% of the feminization activity, but then say Subject XX has 100% of saturation with natural estrogen, and they consume the same precent of phytoestrogens, then they would have 150% of the total binding sites worth of estrogen binders fighting for 100% of the slots, thus one would end up with a ratio of about 2:1 natural estrogen to phytoestrogen, bringing their effectiveness down to 82% (66% (two thirds of the estrogen binding sites bind with natural estrogen) and 16% (one third of the binding sites bind with a phytoestrogen, which is half as effective)). So... yes, lots of text here very little said. Basically, to answer you, soy uses phytoestrogens for feminization (whose most promonent feature is breast development.) --Puellanivis 21:57, 26 July 2006 (UTC)
[edit] Gender reassignment therapy?
How about something on its role in gender reassignment therapy? I know that transsexuals in Indonesia take the contraceptive pill (I think once every two days or four days or something) in order to develop female characteristics. --Singkong2005
[edit] Oestrogen or Estrogen
Surely the title of this article should be Oestrogen, as it is the most widely used spelling Chefette1223 17:33, 27 September 2006 (UTC)
Surely not. Estrogen is more widely used. 14 million hits on Google for estrogen vs 2 million.—Who123 16:31, 29 September 2006 (UTC)
Oestrogen is probably the most commonly used spelling globally in the scientific world. Estrogen is used primarily in the US, and the number of hits on Google probably reflects the Internet usage in the US. The word is derived from the Greek and historically began with an oe ligature.
Who cares what the more common spelling in the "scientific world" is? Wikipedia is an encyclopedia for everyone. So if Estrogen is the more common spelling in *the* world (and I don't know if it is or not), then Wikipedia should use that. 71.206.199.209 02:27, 14 March 2007 (UTC)
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- It's a science article. Estrogen is U.S spelling. That over half of English speakers on the web are American always skews the 'google hits' argument. This is supposed to be an encyclopaedia (sp, lol) not an encyclopedia of U.S. usage. Hakluyt bean (talk) 19:04, 22 March 2008 (UTC)
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- The articles on Google Scholar prefer estrogen over oestrogen 9:1, and the pages on Google in general prefer estrogen to oestrogen almost 10:1. There are no two ways about it: estrogen is the more common spelling. Strad (talk) 01:35, 23 March 2008 (UTC)
[edit] Inaccurate summary of health risks
Removed the following inaccurate sentences:
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- It is now accepted as very likely that estrogen replacement therapy increases the risks of endometrial cancer, breast cancer, heart attacks, strokes, blood clots, and dementia.
- The labeling of estrogen-containing products in the U.S. includes a warning alerting to these risks.[1]
- It has been known for over three decades that unopposed estrogen (without a progestogen) increases the risk of endometrial cancer.
- It is highly controversial, not "now accepted as very likely", that estrogen replacement therapy increases the risks of breast cancer, heart attacks, strokes, blood clots, and dementia.
- The cited important warning of risks included as boxed warnings are for estrogen-only products for postmenopausal women, not for all estrogen-containing products.
69.208.166.122 16:28, 26 October 2006 (UTC)
[edit] estrogen in environment
i am reading this discussion about estrogens being hard to break down, and so they make their way to rivers via female products, nappies, etc. this then tinkers with sexuality of fish, males, etc. anyone have info about this? --ti 18:14, 29 October 2006 (UTC)
Leading to the topic of estrogen pollution Googled Here. Nice article at The Dire Effects of Estrogen Pollution Estrogen from environment enters human food chain or is injected into it by farmers. It is also used in various chemical products such as plastics (water/milk/soda packaging). Increased estrogen in humans can cause premature brest growth in children, man brest, testicle and prostate cancers, as well as other cancers, depression and dementia, and even low sperm count and infertility. All from the "material we call plastics". Also, "got milk" is loaded with estrogen since cows are injected to produce more. If you are a guy and have cerial every morning, you are a gambler. Organic milk might be better but cow is still an estrogen producing female. -- 07:43, 29 November 2006 (UTC)
- Here what might happen with synthetic estrogen pollution (from PNAS:
Collapse of a fish population after exposure to a synthetic estrogen. Interesting... Cyrus Grisham 20:08, 23 May 2007 (UTC)
[edit] Estrogens is the spelling preferred by 5 of 6 web users, and also by 12 out of every 13 scientists studying Estrogen
The article would be greatly improved by acknowledging the alternative spelling at the outset -- "Estrogens (alternatively Oestrogens) are ... " and throughout the rest of the article using the preferred "estrogens" spelling.
A Google search turns up 3,500,000 references to Estrogens -- almost five times as many as the 750,000 references to "Oestrogens." A search of PubMed reveals that the preference for the spelling Estrogens is even stronger in published scientific articles. In PubMed the search term ESTROGENS[Text Word] received 55,000 hits; the term OESTROGENS[Text Word] was far less preferred -- less than 4,000 hits.
The current articles odd use of a minority spelling throws off the flow of the article, as it is jarring to most readers. Moreover, it is flagged by the Firefox spell checker (and Microsoft Word's) as incorrect. The current article's preference of the uncommon addition of the superfluous initial silent "o" undercuts the perceived authority of the article, particularly when this spelling will be perceived by many as a spelling error (and by the better-informed as an idiosyncratic preference for an unusual and archaic word form). —The preceding unsigned comment was added by 67.101.69.40 (talk) 20:43, 16 December 2006 (UTC).
- Agreed and moved. Strad 20:19, 27 December 2006 (UTC)
[edit] osteoporosis and weight?
My professor says that the reason that slender postmenopausal women suffer more from osteoporosis is because they metabolize their fats more quickly which have absorbed estrogens throughout their development, and that this liberation of fats is more effective in keeping large ladies healthy. I cannot find any sources to verify this. does anyone know?217.149.148.54 14:04, 13 June 2007 (UTC)
[edit] Foods containing natural estrogen
A number of different foods and herbs are sources of natural plant estrogens, and can be very helpful during menopause, The following is a list of some of the best food sources of estrogen. These foods are also high in vitamins, minerals, fiber, and essential fatty acids, and they are low in saturated fat. In other words, they are nutritious and should be part of your diet on a regular basis.
Alfalfa Animal flesh Anise seed Apples Baker's yeast Barley Beets Carrots Cherries Chickpeas Clover Cowpeas (black- eyed peas) Cucumbers Dairy Foods Dates Eggs Eggplant Fennel Flaxseeds Garlic Hops Licorice Oats Olive oil Olives Papaya Parsley Peas Peppers Plums Pomegranates Potatoes Pumpkin Red beans Red clover Rhubarb Rice Sage Sesame seeds Soybean sprouts Soybeans Split peas Sunflower seeds Tomatoes Wheat Yams —Preceding unsigned comment added by CCLiCKK (talk • contribs) 08:11, 20 October 2007 (UTC)
Don't forget Bourbon and beer! Referrence is in phytoestrogens article.Pustelnik (talk) 01:13, 5 January 2008 (UTC)
[edit] Estrogens in cosmetics
The article says (copy&paste): "Some hair shampoos on the market include estrogens and placental extracts; others contain phytoestrogens. There are case reports of young children developing breasts after exposure to these shampoos. [21] These products are especially popular with African-American consumers.[22][23]"
The way this is phrased would almost make one think that African-American consumers like these shampoos because they give young children breasts. I think there must be another reason why they prefer the shampoos. Perhaps because of another characteristic of the shampoo that is not described here, like being good for tightly curled hair or something - the estrogen effects being unfortunate side-effects. Olav L (talk) 21:35, 7 December 2007 (UTC)
Actually, these products have been a real clinical problem in the past. Maybe we could avoid the problem by requiring "placental extract" to be referred to as "ground up afterbirths". I changed the wording to refer to marketing, rather than consumer popularity. Does that work? Pustelnik (talk) 01:22, 5 January 2008 (UTC)
- I understand these products can be a problem and I certainly believe you if you say they actually were. But I still don't understand why any kind of shampoo should contain "estrogens and placental extracts". Or why these products should be marketed to (and/or be popular with) black people. I mean, what are these shampoos actually supposed to do and why only for black people? Olav L (talk) 20:56, 22 January 2008 (UTC)
[edit] Functions
Doesn't citation [15] in Medical Applications, http://archpedi.ama-assn.org/cgi/content/short/160/10/1013, regarding estrogen as a height attenuation treatment contradict the statement about estrogen's role in "accelerating height growth" under the heading 'Functions'? I'm no scientist, just a sucker for logic. Please correct me if I'm wrong. Cordof3 (talk) 02:42, 5 March 2008 (UTC)cordof3
- Thanks for pointing out the logical inconsistency. I have changed the wording from accelerate to decelerate, although I am not sure that the later is the best term to use. Cheers. Boghog2 (talk) 06:24, 5 March 2008 (UTC)
Yes, that would sort of make sense. Doesn't the word "attenuate" work as well here as it does later on in the article? Thanks for responding.Cordof3 (talk) 17:43, 7 March 2008 (UTC)Cordof3
