Epoxide hydrolase
From Wikipedia, the free encyclopedia
| Identifiers | |
| Symbol | EPHX1 |
| Alt. Symbols | EPHX |
| Entrez | 2052 |
| HUGO | 3401 |
| OMIM | 132810 |
| RefSeq | NM_000120 |
| UniProt | P07099 |
| Other data | |
| EC number | 3.3.2.3 |
| Locus | Chr. 1 q42.1 |
|
epoxide hydrolase 2, cytoplasmic
|
|
| Identifiers | |
| Symbol | EPHX2 |
| Entrez | 2053 |
| HUGO | 3402 |
| OMIM | 132811 |
| RefSeq | NM_001979 |
| UniProt | P34913 |
| Other data | |
| Locus | Chr. 8 p21 |
Epoxide hydrolase (also known as Epoxide hydratase) functions in detoxication during drug metabolism. It converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body.
Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.
[edit] External links
|
|||||
