EPHX1

From Wikipedia, the free encyclopedia

Epoxide hydrolase 1, microsomal (xenobiotic)

Identifiers

EPHX1; EPHX; EPOX; MEH

External IDs

Gene ontology
Molecular Function:	• epoxide hydrolase activity • hydrolase activity
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• xenobiotic metabolic process • response to toxin • aromatic compound catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000120 (mRNA)
NP_000111 (protein)

NM_010145 (mRNA)
NP_034275 (protein)

Location

Chr 1: 224.06 - 224.1 Mb

Chr 1: 182.83 - 182.85 Mb

Pubmed search

[1]

[2]

Epoxide hydrolase 1, microsomal (xenobiotic), also known as EPHX1, is a human gene.^[1]

Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic).

[edit] Further reading

Seidegård J, Ekström G (1997). "The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.". Environ. Health Perspect. 105 Suppl 4: 791-9. PMID 9255563.
Wormhoudt LW, Commandeur JN, Vermeulen NP (1999). "Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.". Crit. Rev. Toxicol. 29 (1): 59-124. PMID 10066160.
Wilson NM, Omiecinski CJ (1989). "Xenobiotic microsomal epoxide hydrolase: 5' sequence of the human gene.". Biochim. Biophys. Acta 1008 (3): 357-8. PMID 2758034.
Strickler SM, Dansky LV, Miller MA, et al. (1985). "Genetic predisposition to phenytoin-induced birth defects.". Lancet 2 (8458): 746-9. PMID 2864485.
Skoda RC, Demierre A, McBride OW, et al. (1988). "Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.". J. Biol. Chem. 263 (3): 1549-54. PMID 2891713.
Jackson MR, Craft JA, Burchell B (1987). "Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase.". Nucleic Acids Res. 15 (17): 7188. PMID 3502697.
Hassett C, Aicher L, Sidhu JS, Omiecinski CJ (1994). "Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.". Hum. Mol. Genet. 3 (3): 421-8. PMID 7516776.
Hassett C, Robinson KB, Beck NB, Omiecinski CJ (1995). "The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization.". Genomics 23 (2): 433-42. doi:10.1006/geno.1994.1520. PMID 7835893.
McGlynn KA, Rosvold EA, Lustbader ED, et al. (1995). "Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2384-7. PMID 7892276.
Gaedigk A, Spielberg SP, Grant DM (1994). "Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.". Pharmacogenetics 4 (3): 142-53. PMID 7920694.
Hartsfield JK, Sutcliffe MJ, Everett ET, et al. (1999). "Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization.". Cytogenet. Cell Genet. 83 (1-2): 44-5. PMID 9925921.
Krovat BC, Tracy JH, Omiecinski CJ (2000). "Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells.". Toxicol. Sci. 55 (2): 352-60. PMID 10828267.
Hattori N, Fujiwara H, Maeda M, et al. (2000). "Epoxide hydrolase affects estrogen production in the human ovary.". Endocrinology 141 (9): 3353-65. PMID 10965908.
Belmahdi F, Chevalier D, Lo-Guidice JM, et al. (2000). "Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population.". Hum. Mutat. 16 (5): 450. doi:10.1002/1098-1004(200011)16:5<450::AID-HUMU28>3.0.CO;2-1. PMID 11058921.
Zusterzeel PL, Peters WH, Visser W, et al. (2001). "A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia.". J. Med. Genet. 38 (4): 234-7. PMID 11283205.
Sarmanová J, Benesová K, Gut I, et al. (2001). "Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.". Hum. Mol. Genet. 10 (12): 1265-73. PMID 11406608.
Farin FM, Janssen P, Quigley S, et al. (2002). "Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease.". Pharmacogenetics 11 (8): 703-8. PMID 11692079.
Coller JK, Fritz P, Zanger UM, et al. (2002). "Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.". Histochem. J. 33 (6): 329-36. PMID 11758809.