Entecavir

From Wikipedia, the free encyclopedia

This article or section includes a list of references or external links, but its sources remain unclear because it lacks in-text citations. You can improve this article by introducing more precise citations.

Entecavir
Systematic (IUPAC) name
2-amino-9-[4-hydroxy-3-(hydroxymethyl)- 2-methylidene-cyclopentyl]-3H-purin-6-one
Identifiers
CAS number	142217-69-4
ATC code	J05AF10
PubChem	153941
DrugBank	APRD00948
Chemical data
Formula	C12H15N5O3
Mol. mass	277.279 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	13%
Metabolism	?
Half life	128–149 hours
Excretion	Renal 62–73%
Therapeutic considerations
Licence data	EU, US
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral

Entecavir (INN) (pronounced /ɛnˈtɛkəvɪr/) is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).

Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

[edit] External links

• Baraclude U.S. website

v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) Anti-herpesvirus (DNA, I) guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine HPV/MC (DNA, I) Imiquimod • Podophyllotoxin Hepatitis B (DNA, VII) Adefovir • Clevudine • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir† Hepatitis C (RNA, IV) Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir† Picornavirus (RNA, IV) Pleconaril† Anti-influenza agents (RNA, V) Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†) HIV (Reverse, VI) See HIV pharm Other antiviral agents general (Inosine, Interferon) †Undergoing clinical trials, not FDA approved.