Enoximone


Enoximone
Systematic (IUPAC) name
4-methyl-5-(4-methylsulfanylbenzoyl)-1,3- dihydroimidazol-2-one
Identifiers
CAS number	77671-31-9
ATC code	C01CE03
PubChem	53708
Chemical data
Formula	C₁₂H₁₂N₂O₂S
Mol. mass	248.302 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	50% (oral)
Protein binding	85%
Metabolism	Hepatic oxidation
Half life	4 to 10 hours
Excretion	Renal (60 to 70%)
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Intravenous

Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.

v • d • e Selective Phosphodiesterase inhibitors (C01CE, G04BE)

PDE1	Vinpocetine

PDE2	EHNA

PDE3	Amrinone, Bucladesine, Enoximone, Milrinone

PDE4	Cilomilast, Etazolate, HT-0712, Ibudilast, Mesembrine, Rolipram

PDE5	Avanafil, Sildenafil, Tadalafil, Udenafil, Vardenafil

v • d • e Cardiac stimulants excluding cardiac glycosides (C01C)

Adrenergic and dopaminergic agents	Etilefrine • Isoprenaline • Norepinephrine • Dopamine • Norfenefrine • Phenylephrine • Dobutamine • Oxedrine • Metaraminol • Methoxamine • Mephentermine • Dimetofrine • Prenalterol • Dopexamine • Gepefrine • Ibopamine • Midodrine • Octopamine • Fenoldopam • Cafedrine • Arbutamine • Theodrenaline • Epinephrine

Phosphodiesterase inhibitors (PDE3I)	Amrinone • Milrinone • Enoximone • Bucladesine

Other cardiac stimulants	Angiotensinamide • Xamoterol • Levosimendan