Talk:Dutasteride
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[edit] problems
On the forums of this site http:// www.hairsite.com/o-alpha.htm it shows some problems of dutasteride, such as the manboobs (gynecomastia) and that it doesn't lower the hairline as well as finasteride; and it does thickness of hair; it works faster but well after a while it stops working, something like that. I'm sure with some looking or some waiting there might be studies with better sources than forums--this article is stubby. Oh and supposedly it's not approved in the USA and some countries, so customs takes it and will destroy it. DyslexicEditor 03:18, 17 March 2006 (UTC)
[edit] Handling/Women
Can someone provide insight into why this chemical shouldn't even -handled- by pregnant women? Is it water soluble? Is it absorbed through the skin? And then, what effects does it cause? Alvis 04:44, 30 August 2007 (UTC)
- Yeah, I read this and was trying to figure it out. I can't find much of anything online about it, other than it causes "A specific birth defect." Does anyone have anything even vaguely reliable on this?Trocisp 13:29, 30 October 2007 (UTC)
- "Avodart can pass through the skin. Therefore, women who are pregnant or may be pregnant should not touch Avodart because it can pass through their skin and may cause a birth defect in their male baby. " (FDA Consumer Infor)
- "The association of a lack of DHT and birth defects is that a woman who has a congenital severe deficiency of 5 alpha reductase can give birth to a male child with abnormalities of his urinary tract and present as a pseudohermaphrodite." (http://www.xandrox.net/faq/faq_ea.htm)
- True, it's not exactly science. A search on PubMed reveals these (among others..):
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- High dose androgen therapy in male pseudohermaphroditism due to 5 alpha-reductase deficiency and disorders of the androgen receptor. (PubMed) —Preceding unsigned comment added by 216.9.142.175 (talk) 03:18, 7 January 2008 (UTC)
- DHT is part of a requirement to develop the sexual structures of a male child. Technically, there would be no problem if a woman pregnant with a girl touching it, however trying to explain those sorts of variations can lead to some women not heeding advice, so the instructions are simply "zomg, don't touch it!" So that mothers who are at risk for this particular teratogenic effect properly stay away from it. It just happens that some extra mothers end up avoiding the tablets unnecessarily. *shrug* not a bad thing in medicine. Basically, testosterone and DHT are both responsible for sexual differentiation and as stated above, there's a condition similar to 5-alpha-reductase deficiency issue for the fetus. --Puellanivis (talk) 17:58, 8 June 2008 (UTC)
