Dihydropyrimidine dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction

5,6-dihydrouracil + NADP⁺ uracil + NADPH + H⁺

Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NADP⁺, whereas its 3 products are uracil, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme class is 5,6-dihydrouracil:NADP+ 5-oxidoreductase.
Other names in common use include:

• dihydrothymine dehydrogenase
• dihydrouracil dehydrogenase (NADP+)
• 4,5-dihydrothymine: oxidoreductase
• DPD
• DHPDH
• dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide, phosphate)
• dihydrouracil dehydrogenase (NADP+)
• DHU dehydrogenase
• hydropyrimidine dehydrogenase
• dihydropyrimidine dehydrogenase (NADP+)

This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GT8, 1GTE, 1GTH, 1H7W, and 1H7X.

[edit] References

• IUBMB entry for 1.3.1.2
• BRENDA references for 1.3.1.2 (Recommended.)
• PubMed references for 1.3.1.2
• PubMed Central references for 1.3.1.2
• Google Scholar references for 1.3.1.2
• FRITZSON P (1960). "Properties and assay of dihydrouracil dehydrogenase of rat liver". J. Biol. Chem. 235: 719–25. PMID 13825299. 
• Shiotani T, Weber G (1981). "Purification and properties of dihydrothymine dehydrogenase from rat liver". J. Biol. Chem. 256: 219–24. PMID 7451435. 

[edit] External links

The CAS registry number for this enzyme class is 9029-01-0.

• IUBMB entry for 1.3.1.2

• KEGG entry for 1.3.1.2

• BRENDA entry for 1.3.1.2

• NiceZyme view of 1.3.1.2

• EC2PDB: PDB structures for 1.3.1.2

• PRIAM entry for 1.3.1.2

• PUMA2 entry for 1.3.1.2

• IntEnz: Integrated Enzyme entry for 1.3.1.2

• MetaCyc entry for 1.3.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0017113: dihydropyrimidine dehydrogenase (NADP+)

• AMIGO entry for GO code 0017113: dihydropyrimidine dehydrogenase (NADP+)