Delta24(241)-sterol reductase

From Wikipedia, the free encyclopedia

In enzymology, a Delta24(241)-sterol reductase (EC 1.3.1.71) is an enzyme that catalyzes the chemical reaction

ergosterol + NADP⁺ ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H⁺

Thus, the two substrates of this enzyme are ergosterol and NADP⁺, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.

[edit] References

• IUBMB entry for 1.3.1.71
• BRENDA references for 1.3.1.71 (Recommended.)
• PubMed references for 1.3.1.71
• PubMed Central references for 1.3.1.71
• Google Scholar references for 1.3.1.71
• Neal WD, Parks LW (1977). "Sterol 24(28) methylene reductase in Saccharomyces cerevisiae". J. Bacteriol. 129: 1375–8. PMID 14922. 
• Zweytick D, Hrastnik C, Kohlwein SD, Daum G (2000). "Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae". FEBS. Lett. 470: 83–7. doi:10.1016/S0014-5793(00)01290-4. PMID 10722850. 

[edit] External links

• IUBMB entry for 1.3.1.71

• KEGG entry for 1.3.1.71

• BRENDA entry for 1.3.1.71

• NiceZyme view of 1.3.1.71

• EC2PDB: PDB structures for 1.3.1.71

• PRIAM entry for 1.3.1.71

• PUMA2 entry for 1.3.1.71

• IntEnz: Integrated Enzyme entry for 1.3.1.71

• MetaCyc entry for 1.3.1.71

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000246: delta24(24-1) sterol reductase

• AMIGO entry for GO code 0000246: delta24(24-1) sterol reductase