Deacetyl-(citrate-(pro-3S)-lyase) S-acetyltransferase

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In enzymology, a deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase (EC 2.3.1.49) is an enzyme that catalyzes the chemical reaction

S-acetylphosphopantetheine + deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH₂COO-->acetate)] phosphopantetheine + [citrate-oxaloacetate-lyase((pro-3S)-CH₂COO-->acetate)]

Thus, the two substrates of this enzyme are S-acetylphosphopantetheine and [[deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]]], whereas its two products are phosphopantetheine and [[[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is S-acetylphosphopantetheine:deacetyl-[citrate-oxaloacetate-lyase((pro -3S)-CH2COO-->acetate)] S-acetyltransferase. Other names in common use include S-acetyl phosphopantetheine:deacetyl citrate lyase, S-acetyltransferase, and deacetyl-[citrate-(pro-3S)-lyase] acetyltransferase.

[edit] References

• IUBMB entry for 2.3.1.49
• BRENDA references for 2.3.1.49 (Recommended.)
• PubMed references for 2.3.1.49
• PubMed Central references for 2.3.1.49
• Google Scholar references for 2.3.1.49
• Singh M, Bottger B, Stewart C, Brooks GC, Srere PA (1973). "S-acetyl phosphopantetheine: deacetyl citrate lyase S-acetyl transferase from Klebsiella aerogenes". Biochem. Biophys. Res. Commun. 53: 1–9. doi:10.1016/0006-291X(73)91392-2. PMID 4741546. 

[edit] External links

The CAS registry number for this enzyme class is 42616-18-2.

• IUBMB entry for 2.3.1.49

• KEGG entry for 2.3.1.49

• BRENDA entry for 2.3.1.49

• NiceZyme view of 2.3.1.49

• EC2PDB: PDB structures for 2.3.1.49

• PRIAM entry for 2.3.1.49

• PUMA2 entry for 2.3.1.49

• IntEnz: Integrated Enzyme entry for 2.3.1.49

• MetaCyc entry for 2.3.1.49

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047187: deacetyl-[citrate-(pro-3S)-lyase S-acetyltransferase]

• AMIGO entry for GO code 0047187: deacetyl-[citrate-(pro-3S)-lyase S-acetyltransferase]