Cofactor of BRCA1

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Cofactor of BRCA1

Identifiers

COBRA1; DKFZP586B0519; NELF-B; NELFB

External IDs

MGI: 1931035 HomoloGene: 9146

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001133009 (mRNA)
XP_001133009 (protein)

NM_021393 (mRNA)
NP_067368 (protein)

Location

Chr 9: 139.27 - 139.29 Mb

Chr 2: 25.02 - 25.03 Mb

Pubmed search

[1]

[2]

Cofactor of BRCA1, also known as COBRA1, is a human gene^[1] that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660). ^[2] COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.^[3]

[edit] References

^ Entrez Gene: COBRA1 cofactor of BRCA1.
^ Narita, Takashi; Yamaguchi, Yuki ; Yano, Keiichi; Sugimoto, Seiji; Chanarat, Sittinan; Wada, Tadashi; Kim, Dong-ki; Hasegawa, Jun; Omori, Masashi; Inukai, Naoto; Endoh, Masaki; Yamada, Tomoko; Handa, Hiroshi (2003). "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex". MOLECULAR AND CELLULAR BIOLOGY 23: 1863–1873. doi:10.1128/MCB.23.6.1863-1873.2003. PMID 12612062.
^ Ye, Q.; Hu, Y.F.; Zhong, H.; Nye, A.C.; Belmont, A.S.; Li, R. (2001). "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations". The Journal of Cell Biology 155 (6): 911-922. doi:10.1083/jcb.200108049.

[edit] Further reading

Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.". Med Res Rev 26 (5): 595-625. doi:10.1002/med.20081. PMID 16838299.
Yamaguchi Y, Takagi T, Wada T, et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.". Cell 97 (1): 41-51. PMID 10199401.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.". J. Biol. Chem. 276 (16): 12951-8. doi:10.1074/jbc.M006130200. PMID 11112772.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Ye Q, Hu YF, Zhong H, et al. (2002). "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.". J. Cell Biol. 155 (6): 911-21. doi:10.1083/jcb.200108049. PMID 11739404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Narita T, Yamaguchi Y, Yano K, et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.". Mol. Cell. Biol. 23 (6): 1863-73. PMID 12612062.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Zhu J, Song S, Jiang Z, et al. (2005). "Characterization of COBRA1 in human breast cancer cell lines using a new polyclonal antibody against COBRA1.". IUBMB Life 56 (3): 161-6. PMID 15185750.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Aiyar SE, Sun JL, Blair AL, et al. (2004). "Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.". Genes Dev. 18 (17): 2134-46. doi:10.1101/gad.1214104. PMID 15342491.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Zhong H, Zhu J, Zhang H, et al. (2005). "COBRA1 inhibits AP-1 transcriptional activity in transfected cells.". Biochem. Biophys. Res. Commun. 325 (2): 568-73. doi:10.1016/j.bbrc.2004.10.079. PMID 15530430.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
McChesney PA, Aiyar SE, Lee OJ, et al. (2006). "Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas.". Cancer Res. 66 (3): 1346-53. doi:10.1158/0008-5472.CAN-05-3593. PMID 16452188.