RDBP

From Wikipedia, the free encyclopedia

RD RNA binding protein

PDB rendering based on 1x5p.

Available structures: 1x5p, 2bz2

Identifiers

Symbol(s)

RDBP; RDP; RD; D6S45; NELF-E

External IDs

OMIM: 154040 MGI: 102744 HomoloGene: 2178

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002904 (mRNA)
NP_002895 (protein)

NM_001045863 (mRNA)
NP_001039328 (protein)

Location

Chr 6: 32.03 - 32.03 Mb

Chr 17: 34.46 - 34.46 Mb

Pubmed search

[1]

[2]

RD RNA binding protein, also known as RDBP, is a human gene.^[1]

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.^[1]

[edit] References

^ ^a ^b Entrez Gene: RDBP RD RNA binding protein.

[edit] Further reading

Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster.". Exp. Clin. Immunogenet. 15 (4): 213-30. PMID 10072631.
Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.". Med Res Rev 26 (5): 595-625. doi:10.1002/med.20081. PMID 16838299.
Surowy CS, Hoganson G, Gosink J, et al. (1990). "The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved.". Gene 90 (2): 299-302. PMID 2119325.
Speiser PW, White PC (1990). "Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex.". DNA 8 (10): 745-51. PMID 2612324.
Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T (1988). "A previously undetected MHC gene with an unusual periodic structure.". Science 240 (4849): 201-4. PMID 3353717.
Cheng J, Macon KJ, Volanakis JE (1993). "cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex.". Biochem. J. 294 ( Pt 2): 589-93. PMID 8373374.
Lee SG, Song K (1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex.". Mol. Cells 7 (3): 414-8. PMID 9264031.
Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.". Nucleic Acids Res. 26 (21): 5007-8. PMID 9776767.
Yang Z, Shen L, Dangel AW, et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.". Genomics 53 (3): 338-47. doi:10.1006/geno.1998.5499. PMID 9799600.
Yamaguchi Y, Takagi T, Wada T, et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.". Cell 97 (1): 41-51. PMID 10199401.
Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.". J. Biol. Chem. 276 (16): 12951-8. doi:10.1074/jbc.M006130200. PMID 11112772.
Yamaguchi Y, Inukai N, Narita T, et al. (2002). "Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.". Mol. Cell. Biol. 22 (9): 2918-27. PMID 11940650.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Narita T, Yamaguchi Y, Yano K, et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.". Mol. Cell. Biol. 23 (6): 1863-73. PMID 12612062.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621-36. doi:10.1101/gr.1736803. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Aiyar SE, Sun JL, Blair AL, et al. (2004). "Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.". Genes Dev. 18 (17): 2134-46. doi:10.1101/gad.1214104. PMID 15342491.