Cob(II)yrinic acid a,c-diamide reductase

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In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction

2 cob(I)yrinic acid a,c-diamide + FMN + 2 H⁺ 2 cob(II)yrinic acid a,c-diamide + FMNH₂

The 3 substrates of this enzyme are cob(I)yrinic acid a,c-diamide, FMN, and H⁺, whereas its two products are cob(II)yrinic acid a,c-diamide and FMNH2.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor. The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect). This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 1.16.8.1
• BRENDA references for 1.16.8.1 (Recommended.)
• PubMed references for 1.16.8.1
• PubMed Central references for 1.16.8.1
• Google Scholar references for 1.16.8.1
• Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174: 7452–4. PMID 1429467. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810. 

[edit] External links

• IUBMB entry for 1.16.8.1

• KEGG entry for 1.16.8.1

• BRENDA entry for 1.16.8.1

• NiceZyme view of 1.16.8.1

• EC2PDB: PDB structures for 1.16.8.1

• PRIAM entry for 1.16.8.1

• PUMA2 entry for 1.16.8.1

• IntEnz: Integrated Enzyme entry for 1.16.8.1

• MetaCyc entry for 1.16.8.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043784: cob(II)yrinic acid a,c-diamide reductase

• AMIGO entry for GO code 0043784: cob(II)yrinic acid a,c-diamide reductase