Cinnamyl-alcohol dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) is an enzyme that catalyzes the chemical reaction

cinnamyl alcohol + NADP⁺ $\rightleftharpoons$ cinnamaldehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are cinnamyl alcohol and NADP⁺, whereas its 3 products are cinnamaldehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cinnamyl-alcohol:NADP+ oxidoreductase. Other names in common use include cinnamyl alcohol dehydrogenase, and CAD. This enzyme participates in phenylpropanoid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1YQD, 1YQX, 2CF5, and 2CF6.

[edit] References

IUBMB entry for 1.1.1.195
BRENDA references for 1.1.1.195 (Recommended.)
PubMed references for 1.1.1.195
PubMed Central references for 1.1.1.195
Google Scholar references for 1.1.1.195
Sarni F, Grand C, Boudet AM (1984). "Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)". Eur. J. Biochem. 139: 259–65. doi:10.1111/j.1432-1033.1984.tb08002.x. PMID 6365550.
Wyrambik D, Grisebach H (1975). "Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures". Eur. J. Biochem. 59: 9–15. doi:10.1111/j.1432-1033.1975.tb02418.x. PMID 1250.
Wyrambik D, Grisebach H (1979). "Enzymic synthesis of lignin precursors. Further studies on cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures". Eur. J. Biochem. 97: 503–9. doi:10.1111/j.1432-1033.1979.tb13138.x. PMID 572771.