Cinnamoyl-CoA reductase

From Wikipedia, the free encyclopedia

In enzymology, a cinnamoyl-CoA reductase (EC 1.2.1.44) is an enzyme that catalyzes the chemical reaction

cinnamaldehyde + CoA + NADP⁺ $\rightleftharpoons$ cinnamoyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are cinnamaldehyde, CoA, and NADP⁺, whereas its 3 products are cinnamoyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating). Other names in common use include feruloyl-CoA reductase, cinnamoyl-coenzyme A reductase, ferulyl-CoA reductase, feruloyl coenzyme A reductase, p-hydroxycinnamoyl coenzyme A reductase, and cinnamoyl-CoA:NADPH reductase. This enzyme participates in phenylpropanoid biosynthesis.

[edit] References

IUBMB entry for 1.2.1.44
BRENDA references for 1.2.1.44 (Recommended.)
PubMed references for 1.2.1.44
PubMed Central references for 1.2.1.44
Google Scholar references for 1.2.1.44
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Sarni F, Grand C, Boudet AM (1984). "Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)". Eur. J. Biochem. 139: 259–65. doi:10.1111/j.1432-1033.1984.tb08002.x. PMID 6365550.
Wengenmayer H, Ebel J, Grisebach H (1976). "Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax)". Eur. J. Biochem. 65: 529–36. doi:10.1111/j.1432-1033.1976.tb10370.x. PMID 7454.