Talk:Chloramphenicol

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Hey, someone wanna track down the use of chloramphenicol for amplification of plasmids within bacteria? I know sometimes they are at least used in E. Coli plasmid amplification of pBR322-derived plasmids: so says my advanced molecular biology lab book. Caraamon 19:07, 11 April 2007 (UTC)

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is chloramphenicol suitable breast feeding mothers as eye drops?

Contents

[edit] Mechanism and resistance

I have attempted some clarification (i.e. addition of "molecule") and spelling fixes for the "Mechanism and resistance" section. However, the beginning section is slightly confusing to me, as it may be interpreted to suggest that peptidyl transferase inhibits ribosome activity:

Chloramphenicol stops bacterial growth by inhibiting the enzyme peptidyl transferase, which inhibits ribosomal activity and protein synthesis.

However, I am guessing that peptidyl transferase does not inhibit ribosome activity...should it be reworded to clarify, perhaps to something like the following?:

Chloramphenicol stops bacterial growth by inhibiting the enzyme peptidyl transferase; the inhibition of this enzyme results in inhibited ribosomal activity, which leads to inhibited protein synthesis.

--GregRM 04:45, 23 March 2006 (UTC)

[edit] Animal use

Is Chloramphenicol used in the treatment of animals? —The preceding unsigned comment was added by Frederickwolf (talkcontribs) 19:07, 15 December 2006 (UTC).

[edit] Use on scars

I've heard that Chlorsig can be an effective treatment to minimise the appearance of scars when applied during the healing process - this was confirmed by a plastic surgeon after a recent procedure. I can't find any reference to this anywhere on the internet however. Has anyone else heard of this use, or have any information about its accuracy? -Orpheus82 03:02, 20 February 2007 (UTC)

[edit] Considerations on the Thiamphenicol

Thiamphenicol is not only for use in animal.
In Italy Thiamphenicol is sold under the commercial name Glitisol for human use.
I do not know in other European countries, but is not used only in China.
Try to see the follow link : http://www.torrinomedica.it/studio/schedefarmaci/GLITISOL.htm
--Scayn 20:08, 12 March 2007 (UTC)

Thanks, added to the article, and to thiamphenicol as well. Fvasconcellos (t·c) 17:46, 11 May 2007 (UTC)