Thiamphenicol

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Thiamphenicol
Systematic (IUPAC) name
2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide
Identifiers
CAS number	15318-45-3
ATC code	J01BA02
PubChem	27200
DrugBank	?
Chemical data
Formula	C₁₂H₁₅Cl₂N O₅S
Mol. mass	356.223 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Half life	5.0 hours
Excretion	renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	none
Routes	IV, IM, O

Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

[edit] Alternative names

Dextrosulphenidol
Thiophenicol

[edit] External links

Overview at World Health Organization - Food and Agriculture Organization
Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars) 64 (1): 33–8. PMID 15224555.
Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy.". J Chemother 14 (6): 554–61. PMID 12583545.