Chitobiosyldiphosphodolichol beta-mannosyltransferase

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In enzymology, a chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) is an enzyme that catalyzes the chemical reaction

GDP-mannose + chitobiosyldiphosphodolichol $\rightleftharpoons$ GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol

Thus, the two substrates of this enzyme are GDP-mannose and chitobiosyldiphosphodolichol, whereas its two products are GDP and beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-dolichol diphosphochitobiose, mannosyltransferase, and GDP-mannose-dolichol diphosphochitobiose mannosyltransferase. This enzyme participates in n-glycan biosynthesis and glycan structures - biosynthesis 1.

[edit] References

IUBMB entry for 2.4.1.142
BRENDA references for 2.4.1.142 (Recommended.)
PubMed references for 2.4.1.142
PubMed Central references for 2.4.1.142
Google Scholar references for 2.4.1.142
Sharma CB, Lehle L, Tanner W (1982). "Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast". Eur. J. Biochem. 126: 319–25. PMID 6215245.
Takahashi T, Honda R, Nishikawa Y (2000). "Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1". Glycobiology. 10: 321–7. doi:10.1093/glycob/10.3.321. PMID 10704531.