Calcium-binding protein 1

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calcium binding protein 1
Identifiers
Symbol CABP1
Entrez 9478
HUGO 1384
OMIM 605563
RefSeq NM_001033677
UniProt Q9NZU7
Other data
Locus Chr. 12 q24.31

Calcium-binding protein 1, also known as caldendrin and calbrain, is a calcium-binding protein discovered in 1999.[1] It has two EF hand motifs and is expressed in neuronal cells in such areas as hippocampus, habenular nucleus of the epithalamus, Purkinje cell layer of the cerebellum, and the amacrine cells and cone bipolar cells of the retina.

Cellular expression of caldendrin is restricted to the somato–dendritic compartment, with the exception of hypothalamus, where axonal labeling was detected.[2]


In schizophrenia, one study demonstrated a decrease in the number of CABP1-expressing cells, specifically in the left dorsolateral prefrontal cortex. This change, however, was compensated on a whole-brain scale by an increase in the protein levels.[3]

[edit] References

  1. ^ Yamaguchi K, Yamaguchi F, Miyamoto O, Sugimoto K, Konishi R, Hatase O, Tokuda M (1999). "Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain". J. Biol. Chem. 274 (6): 3610–6. PMID 9920909. 
  2. ^ Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2003). "Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain". J. Histochem. Cytochem. 51 (8): 1109–12. PMID 12871994. 
  3. ^ Bernstein HG, Sahin J, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2007). "A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia". Schizophrenia Research 96 (1-3): 246–56. doi:10.1016/j.schres.2007.05.038. PMID 17719205. 
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