Talk:BUN-to-creatinine ratio

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[edit] Cimetidine

Do H2RA's (cimetidine specifically) decrease BUN:Cr? I always thought that H2RA's block cimetidine secretion into the tubule, so presumably they decrease BUN:Cr? -- Samir धर्म 02:31, 25 June 2006 (UTC)

This article touches on the subject.

Here is a ref (Ixkes MC, Koopman MG, van Acker BA, Weber JA, Arisz L. Cimetidine improves GFR-estimation by the Cockcroft and Gault formula. Clin Nephrol. 1997 Apr;47(4):229-36. PMID 9128789.) that suggests-- cimetidine increases the GFR. So, I'd think it would decrease the BUN/Cr ratio (at least transisently). AFAIK, based on the mass transfer theory I learned, the BUN/Cr ratio changes because the mass generation rates of creatinine and urea are different--I have to find a ref for that though.

My question at the moment is-- is the sensitivity for detecting GI bleeding due to bleeding induced hypovolemia? <--That is my theory... I'm looking for something in the literature to confirm that hunch. Nephron  T|C 03:04, 25 June 2006 (UTC)