BOP reagent

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BOP reagent
IUPAC name	Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate
Other names	Castro's reagent
Identifiers
CAS number	[56602-33-6]
SMILES	CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1.[F-].FP(F)(F)(F)F
Properties
Molecular formula	C12H22F6N6OP2
Molar mass	442.281 g/mol
Appearance	White crystalline powder
Melting point	136 - 140 °C
Solubility in water	Partially soluble in cold water
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

BOP-reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA, which is carcinogenic.

[edit] See also

• PyBOP, a related reagent