Talk:Blood-brain barrier

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New research indicates that the drug ecstasy "may damage" the blood-brain barrier: http://www.newscientist.com/article.ns?id=dn8314

Too tired to write it up. Have at it, boys.

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[edit] Blood-brain barrier

Has anybody have any notes on affects of cell-phones on the Blood Brain Barrier?

hydkat 05:52, 19 December 2005 (UTC)

See http://www.ehponline.org/docs/2003/6039/abstract.html.


For orally administered drugs there seems to be some guidelines, see: http://en.wikipedia.org/wiki/Lipinski's_Rule_of_Five

Also try, Proudfoot, Bioorganic and Medicinal Chemistry Letter 15, 1087

/mfg

[edit] Drugs Targeting the Brain

If dye can travel from the spine to the brain, why can't we administer drugs to the brain by injecting it into the spine?

because getting needles stuck into cerebral fluid not only is dangerous, but it really hurts.

[edit] Permeability to alcohol

I mentioned in the article that the BBB is permeable to alcohol, but I didn't go into details explaining thats why the feeling of being drunk affects people when they drink (having alcohol in their blood-stream). Darwin's Bulldog 16:54, 4 June 2006 (UTC)

[edit] L-DOPA?

"[...] the endothelial cells metabolize certain molecules to prevent their entry into the central nervous system; the most-studied example of this is L-DOPA."

According to the L-DOPA Wikipedia entry, its is dopamine itself that is unable to traverse the BBB, and it is the ability of L-DOPA to cross the BBB that is responsible for its mechanism of action.

What's the deal? -- Mark Lundquist 00:35, 17 August 2006 (UTC)


Yeah L-Dopa is used for Parkinson's as it can get through the BBB. You're right

[edit] BAFFLING REDIRECTION?

This is the sort of thing that undermines Wikipedia's reputation:


"Blood-brain Barrier

(Redirected from Blood-cerebrospinal fluid barrier)

The blood-brain barrier (abbreviated BBB, not to be confused with the blood-cerebrospinal fluid barrier... )"

Well played, Wikipedia, well played.

Hey, I'm not the only one who came here to point this out. Any experts want to start an article on the blood-CSF barrier, if, indeed, it is disctinct from the BBB?

[edit] Mistake or just a typo?

Glial cells surrounding capilaries in the brain pose a secondary hindrance to hydrophillic molecules, and the low concentration of interstitial proteins in the brain prevent access by hydrophilic molecules.

Hydrophillic and hydrophilic. Is there just an extra l or should one of these be hydrophobic instead? --TuukkaH 20:04, 17 November 2006 (UTC)

Somebody fixed the typo, but does this sentence now make sense? I have no expertise here at all, but from the semantics, it certainly seems as if one of these words should be hydrophobic (I would guess the first one). Would someone who knows please fix this (if it is, in fact, incorrect)?Eaglizard 18:50, 6 May 2007 (UTC)

[edit] Ependymal cells??

This entry had the following in the opening section: "Astrocytes, a type of glial cell specific to the central nervous system, form a tight barrier between the blood capillaries of the brain and the ependymal cells lining the ventricles of the brain." I cannot see the relevance of this. Astrocytes support the epithelial cells of the BBB, but are not an essential part. I am deleting this sentence and adding something more relevant. —The preceding unsigned comment was added by Benbest (talk • contribs) 06:05, 17 February 2007 (UTC).

Oops! --Ben Best 13:06, 17 February 2007 (UTC)

[edit] Bit of cleanup

I rewrote most of the sections of this article slightly to make them more readable to the lay audience (ie, myself). As always, I tried to avoid changing the factual substance of anything, as I am completely inexpert in this field. I have faith any errors I have introduced will be quickly healed. :) I hope my complete rewrite of the first (and most important) paragraph is satisfactory, in particular. It does seem to me that the last sections (the various specific diseases) devolve into heavily obscure jargon, but I don't feel qualified to mess with those. Eaglizard 18:50, 6 May 2007 (UTC)

[edit] When is the blood-brain barrier in place?

At birth, or later? —Preceding unsigned comment added by 71.194.21.50 (talk) 13:31, 27 September 2007 (UTC)