Benzaldehyde dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a benzaldehyde dehydrogenase (NADP+) (EC 1.2.1.7) is an enzyme that catalyzes the chemical reaction

benzaldehyde + NADP⁺ + H₂O benzoate + NADPH + 2 H⁺

The 3 substrates of this enzyme are benzaldehyde, NADP⁺, and H₂O, whereas its 3 products are benzoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzaldehyde:NADP+ oxidoreductase. Other names in common use include NADP+-linked benzaldehyde dehydrogenase, and benzaldehyde dehydrogenase (NADP+). This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation.

[edit] References

• IUBMB entry for 1.2.1.7
• BRENDA references for 1.2.1.7 (Recommended.)
• PubMed references for 1.2.1.7
• PubMed Central references for 1.2.1.7
• Google Scholar references for 1.2.1.7
• GUNSALUS CF, STANIER RY, GUNSALUS IC (1953). "The enzymatic conversion of mandelic acid to benzoic acid. III Fractionation and properties of the soluble enzymes". J. Bacteriol. 66: 548–53. PMID 13108854. 
• Stachow CS, Stevenson IL, Day D (1967). "Purification and properties of nicotinamide adenine dinucleotide phosphate-specific benzaldehyde dehydrogenase from Pseudomonas". J. Biol. Chem. 242: 5294–300. PMID 4383635. 

[edit] External links

The CAS registry number for this enzyme class is 9028-89-1.

• IUBMB entry for 1.2.1.7

• KEGG entry for 1.2.1.7

• BRENDA entry for 1.2.1.7

• NiceZyme view of 1.2.1.7

• EC2PDB: PDB structures for 1.2.1.7

• PRIAM entry for 1.2.1.7

• PUMA2 entry for 1.2.1.7

• IntEnz: Integrated Enzyme entry for 1.2.1.7

• MetaCyc entry for 1.2.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018477: benzaldehyde dehydrogenase (NADP+)

• AMIGO entry for GO code 0018477: benzaldehyde dehydrogenase (NADP+)