Talk:Bcl-2
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[edit] Corrected links and some concepts
I removed the paragraph entitled 'Bim' because it seemed to be extraneous info and didn't make a lot of sense. Reference link was also incorrect. Don't think one member of the family should get its own paragraph if no others do. Berry 15:05, 26 April 2006 (UTC)
I changed MMP to MOMP because 1) MOMP is standard in the literature, and 2) MMP is the common abbreviation for the matrix metalloproteinases. I removed PT (permeability transition) because 1) PTP is the more common abbreviation, and 2) it wasn't used anywhere else in the article anyway. EquationDoc 02:00, 9 November 2006 (UTC)
Added links for Bak, Bax, and Bcl-xL in "Function". Deleted "MOM" because this abbreviation is irrelevant in the text. Changed the "believed" mechanism for Bcl-2 regulation of the mitochondrial outer membrane permeabilization for the latest available information regarding the oligomerization of Bax and/or Bak to form a pore in the outer membrane, as well as its blocking by Bcl-2, thus eliminating the vague MOMP concept. Pablufu 11:10, 02 January 2008 (UTC)
At some point I'd like to break this page into two, one describing the Bcl-2 protein, and one describing the Bcl-2 family of proteins (say, Bcl-2_Proteins), thus opening up the possibility for individual pages for each of the 25 or so Bcl-2 proteins. EquationDoc 02:00, 9 November 2006 (UTC)
[edit] Format/Editing/Citations
I feel that there are some serious weaknesses in this article-- for example, there is an in-text citation in the paragraph of Bcl-2 and the role it plays in cancer, and the citation is for a study that is almost 20 years old, and extremely obsolete. I feel that this is poor research, and I do not feel comfortable editing it since I have only undergraduate experience with molecular biology. Can someone with more experience in the field take a look at the information and take a try at editing it?--Nakedophelia 22:51, 15 November 2007 (UTC)
The figure showing the domain structure/organization is not correct. Mcl-1 (and probably A1 as well as others) does not possess a BH4 domain (Bcl-2 does however). See the domains contained in Mcl-1 here: http://www.ebi.ac.uk/interpro/ISpy?mode=single&ac=Q07820 —Preceding unsigned comment added by 35.9.6.175 (talk) 14:06, 18 May 2008 (UTC)
