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Stephen T. Warren, American geneticist, received his PhD in Human Genetics from Michigan State University in 1981 and was then a fellow at the University of Illinois. In 1984, he was also a visiting scientist at the European Molecular Biology Laboratory. In 1985 he joined the Emory faculty and currently is Professor and Chair of Human Genetics as well as Professor of Biochemistry and Pediatrics. For 11 years, until he founded the Department of Human Genetics, Dr. Warren was an Investigator of the Howard Hughes Medical Institute. Dr. Warren is a Diplomat of the American Board of Medical Genetics and currently serves on the National Institute of Mental Health Council. From 1999 until 2005, Dr. Warren was Editor-in-Chief of The American Journal of Human Genetics and in 2005 served as President of the American Society of Human Genetics. Among his awards are the Albert E. Levy Faculty Award from Emory University, the Rosen Research Award from the National Fragile X Foundation (awarded twice), a MERIT award from the NIH and the William Allan Award from the American Society of Human Genetics. In 2003, he was an inaugural inductee of the National Institute of Child Health and Human Development’s Hall of Honor for the “identification of triplet repeat expansion as the cause of fragile X syndrome and as an entirely new inherited mechanism of genetic disease”. In 2004, he was elected to the Institute of Medicine of the National Academies. In 2007, Dr. Warren was presented the Outstanding Alumni Award from Michigan State University.
[edit] Sources
Warren ST, Zhang F, Licameli GR & Peters JF. The fragile X site in somatic cell hybrids: An approach for molecular cloning of fragile sites. Science 237:420-423 (1987). Verkerk AJMH, Pieretti M, Sutcliffe JS, Fu Y-H, Kuhl DPA, Pizzuti A, Reiner O, Richards S, Victoria MF, Zhang F, Eussen BE, van Ommen GLB, Blonden LAJ, Riggins GJ, Chastain JL, Kunst CB, Gakljaard H, Caskey CT, Nelson DL, Oostra BA & Warren ST. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65:905-914 (1991). Yu, S, Kremer, E, Pritchard, M, Lynch, M, Nancarrow, J, Baker, E, Holman, K, Mulley, JC, Warren, ST, Schlessinger, D, Sutherland, GR and Richards, RI: The fragile X genotype is characterized by an unstable region of DNA. Science 252:1179-1181 (1991). Kremer, EJ, Pritchard, M, Lynch, M, Yu, S, Holman, K, Baker, E, Warren, ST, Schlessinger, D, Sutherland, GR and Richards, RI: Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Science 252:1711-1714 (1991). Pieretti, M, Fu, Y-H, Warren, ST, Zhang, F, Oostra, BA, Caskey, CT and Nelson, DL: Absence of expression of the FMR-1 gene in fragile X syndrome. Cell 66:817-822 (1991). Fu, Y-H, Kuhl, DPA, Pizzuti, A, Pieretti, M, Sutcliffe, JS, Richards, S, Verkerk, JMH, Holden, JJA, Fenwick, RG, Warren, ST, Oostra, BA, Nelson, DL and Caskey, CT: Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox. Cell 67:1047-1058 (1991). Riggins, GJ, Lokey, LK, Chastain, JL, Leiner, HA, Sherman, SL, Wilkinson, KD and Warren, ST: Human genes containing polymorphic trinucleotide repeats. Nat Genet 2:186-191 (1992). Ashley CT, Wilkinson KD, Reines D & Warren ST. FMR1 protein: Conserved RNP family domains and selective RNA binding. Science 262:563-566 (1993). Kunst CB & Warren ST. Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles. Cell 77:853-861 (1994). Feng Y, Zhang F, Lokey LK, Chastain JL, Lakkis L, Eberhart D & Warren ST. Translational suppression by trinucleotide repeat expansion at FMR1. Science 268:731-734 (1995). Brown, V, Jin, P, Ceman, S, Darnell, JC, O’Donnell, WT, Tenenbaum, SA, Jin, X, Feng, Y, Wilkinson, KD, Keene, JD, Darenll, RB and Warren, ST: Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107:477-487 (2001). O’Donnell, WT and Warren, ST: A decade of molecular studies of fragile X syndrome. Ann Rev Neurosci 25:315-338 (2002). Jin, P, Zarnescu, DC, Zhang, F, Pearson CE, Lucchesi, JC, Moses, K, and Warren, ST: RNA-mediated neurodegeneration caused by the fragile X premutation in Drosophila. Neuron 39:739-747 (2003). Jin, P, Zarnescu, DC, Ceman, S, Nakamoto, M, Mowrey, J, Jongens, TA, Nelson, DL, Moses, K, and Warren, ST: Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neurosci 7:113-117 (2004). Bear, MF, Huber, KM and Warren, ST: The mGluR theory of fragile X mental retardation. Trends Neurosci 27:370-377 (2004). Jin, P, Alisch, RS, and Warren, ST: RNA and microRNAs in fragile X mental retardation. Nature Cell Bio 11:1048-1053 (2004). Penagarikano, O, Mulle, JG and Warren ST: The pathophysiology of fragile X syndrome. Annu Rev Genomics Hum Genet 8: (2007). Jin, P, Duan, R, Qurashi, A, Qin, Y, Tian, D, Rosser, TC, Liu, H, Feng, Y and Warren, ST: Pur α binds to rCGG repeats and modulated repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. Neuron 55:556-564 (2007). Nakamoto, M, Nalavadi, V, Epstein, MP, Narayanan, U, Bassell, GJ and Warren, ST: Fragile X mental retardation protein deficiency leads to spontaneous mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci, USA 104:15537-15542 (2007). Friedman, M, Fang, Z-H, Shah, A, de Goursac, E, Warren, ST, Li, S, and Li, X-J: Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nature Neurosci 10:1519-1528 (2007). Narayan, U, Nalavadi, V, Nakamoto, M, Pallas, D, Ceman, S, Bassell, GJ and Warren, ST: FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group1 mGluR and mediated by PP2A. J Neurosci 27:14349-14357 (2007). Chang, S, Bray, SM, Li, Z, Zarnescu, DC, He, C, Jin, P and Warren, ST: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nature Chem-Biol 4:256-263 (2008).
170.140.228.233 (talk) 17:19, 2 April 2008 (UTC)
Declined. We cannot accept unsourced suggestions or sources that are not reliable per the verifiability policy. Please provide reputable, third-party sources with your suggestions. Third party sources are needed both to establish the verifiability of the submission as well as its notability. All the sources you provided were primary sources, so none would be about Stephen Warren himself. Graeme Bartlett (talk) 20:40, 2 April 2008 (UTC)
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