Amorolfine

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Amorolfine
Systematic (IUPAC) name
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4- (2-methylbutan-2-yl)phenyl]propyl]morpholine
Identifiers
CAS number	78613-35-1
ATC code	D01AE16
PubChem	54260
Chemical data
Formula	C21H35N
Mol. mass	317.509 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.

v • d • e Antifungals (D01 and J02) Antibiotics Griseofulvin • polyene antimycotics (Natamycin, Nystatin) Topical azoles imidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Neticonazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole) Other topicals Ciclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine) For systemic use Griseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin) Other Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle