Alpha,alpha-trehalose-phosphate synthase (GDP-forming)

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In enzymology, an alpha,alpha-trehalose-phosphate synthase (GDP-forming) (EC 2.4.1.36) is an enzyme that catalyzes the chemical reaction

GDP-glucose + glucose 6-phosphate GDP + alpha,alpha-trehalose 6-phosphate

Thus, the two substrates of this enzyme are GDP-glucose and glucose 6-phosphate, whereas its two products are GDP and alpha,alpha'-trehalose 6-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase. Other names in common use include GDP-glucose-glucose-phosphate glucosyltransferase, guanosine diphosphoglucose-glucose phosphate glucosyltransferase, and trehalose phosphate synthase (GDP-forming).

[edit] References

• IUBMB entry for 2.4.1.36
• BRENDA references for 2.4.1.36 (Recommended.)
• PubMed references for 2.4.1.36
• PubMed Central references for 2.4.1.36
• Google Scholar references for 2.4.1.36
• Elbein AD (1967). "Carbohydrate metabolism in Streptomyces hygroscopicus. I. Enzymatic synthesis of trehalose phosphate from guanosine diphosphate D-glucose-14C". J. Biol. Chem. 242: 403–6. PMID 6022837. 

[edit] External links

The CAS registry number for this enzyme class is 37257-32-2.

• IUBMB entry for 2.4.1.36

• KEGG entry for 2.4.1.36

• BRENDA entry for 2.4.1.36

• NiceZyme view of 2.4.1.36

• EC2PDB: PDB structures for 2.4.1.36

• PRIAM entry for 2.4.1.36

• PUMA2 entry for 2.4.1.36

• IntEnz: Integrated Enzyme entry for 2.4.1.36

• MetaCyc entry for 2.4.1.36

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047260: alpha,alpha-trehalose-phosphate synthase (GDP-forming)

• AMIGO entry for GO code 0047260: alpha,alpha-trehalose-phosphate synthase (GDP-forming)