Aldose-6-phosphate reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, an aldose-6-phosphate reductase (NADPH) (EC 1.1.1.200) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NADP⁺ D-glucose 6-phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NADP⁺, whereas its 3 products are D-glucose 6-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP+ 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP+-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP+ 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).

[edit] References

• IUBMB entry for 1.1.1.200
• BRENDA references for 1.1.1.200 (Recommended.)
• PubMed references for 1.1.1.200
• PubMed Central references for 1.1.1.200
• Google Scholar references for 1.1.1.200
• Negm FB and Loescher WH (1981). "Characterization and partial-purification of aldose-6-phosphate reductase (alditol-6-phosphate-NADP 1-oxidoreductase) from apple leaves". Plant Physiol. 67: 139–142. 

[edit] External links

The CAS registry number for this enzyme class is 76901-04-7.

• IUBMB entry for 1.1.1.200

• KEGG entry for 1.1.1.200

• BRENDA entry for 1.1.1.200

• NiceZyme view of 1.1.1.200

• EC2PDB: PDB structures for 1.1.1.200

• PRIAM entry for 1.1.1.200

• PUMA2 entry for 1.1.1.200

• IntEnz: Integrated Enzyme entry for 1.1.1.200

• MetaCyc entry for 1.1.1.200

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047641: aldose-6-phosphate reductase (NADPH)

• AMIGO entry for GO code 0047641: aldose-6-phosphate reductase (NADPH)