ADAM23

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ADAM metallopeptidase domain 23
Identifiers
Symbol(s) ADAM23; MDC3
External IDs OMIM: 603710 MGI: 1345162 HomoloGene: 2826
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8745 23792
Ensembl ENSG00000114948 ENSMUSG00000025964
Uniprot O75077 Q5SRA3
Refseq NM_003812 (mRNA)
NP_003803 (protein)		 XM_622578 (mRNA)
XP_622578 (protein)
Location Chr 2: 207.02 - 207.19 Mb Chr 1: 63.38 - 63.53 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 23, also known as ADAM23, is a human gene.[1]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[1]

[edit] References

  1. ^ a b Entrez Gene: ADAM23 ADAM metallopeptidase domain 23.

[edit] Further reading

  • Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.". Biochem. J. 334 ( Pt 1): 93-8. PMID 9693107. 
  • Roberts CM, Tani PH, Bridges LC, et al. (1999). "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes.". J. Biol. Chem. 274 (41): 29251-9. PMID 10506182. 
  • Poindexter K, Nelson N, DuBose RF, et al. (1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.". Gene 237 (1): 61-70. PMID 10524237. 
  • Cal S, Freije JM, López JM, et al. (2000). "ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism.". Mol. Biol. Cell 11 (4): 1457-69. PMID 10749942. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sun YP, Deng KJ, Wang F, et al. (2004). "Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains.". Gene 325: 171-8. PMID 14697522. 
  • Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.". Nat. Biotechnol. 22 (6): 724-31. doi:10.1038/nbt969. PMID 15146195. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Costa FF, Colin C, Shinjo SM, et al. (2005). "ADAM23 methylation and expression analysis in brain tumors.". Neurosci. Lett. 380 (3): 260-4. doi:10.1016/j.neulet.2005.01.050. PMID 15862898. 
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384. 
  • Takada H, Imoto I, Tsuda H, et al. (2005). "ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.". Oncogene 24 (54): 8051-60. doi:10.1038/sj.onc.1208952. PMID 16103878. 
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v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinase
Other