ADAM22

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ADAM metallopeptidase domain 22
Identifiers
Symbol(s) ADAM22; MDC2; MGC149832
External IDs OMIM: 603709 MGI: 1340046 HomoloGene: 37898
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 53616 11496
Ensembl ENSG00000008277 ENSMUSG00000040537
Uniprot Q9P0K1 Q9R1V6
Refseq NM_004194 (mRNA)
NP_004185 (protein)		 NM_001007220 (mRNA)
NP_001007221 (protein)
Location Chr 7: 87.4 - 87.66 Mb Chr 5: 8.08 - 8.37 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 22, also known as ADAM22, is a human gene.[1]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: ADAM22 ADAM metallopeptidase domain 22.

[edit] Further reading

  • Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.". Biochem. J. 334 ( Pt 1): 93–8. PMID 9693107. 
  • Poindexter K, Nelson N, DuBose RF, et al. (1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.". Gene 237 (1): 61–70. PMID 10524237. 
  • Harada T, Nishie A, Torigoe K, et al. (2001). "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas.". Jpn. J. Cancer Res. 91 (10): 1001–6. PMID 11050470. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhu P, Sun Y, Xu R, et al. (2003). "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.". Biochem. Biophys. Res. Commun. 301 (4): 991–9. PMID 12589811. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
  • Sagane K, Hayakawa K, Kai J, et al. (2006). "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.". BMC neuroscience 6 (1): 33. doi:10.1186/1471-2202-6-33. PMID 15876356. 
  • Zhu P, Sang Y, Xu H, et al. (2005). "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3.". Biochem. Biophys. Res. Commun. 331 (4): 938–46. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • D'Abaco GM, Ng K, Paradiso L, et al. (2006). "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.". Neurosurgery 58 (1): 179–86; discussion 179–86. PMID 16385342. 
  • Gödde NJ, D'Abaco GM, Paradiso L, Novak U (2006). "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.". J. Cell. Sci. 119 (Pt 16): 3296–305. doi:10.1242/jcs.03065. PMID 16868027. 
  • Fukata Y, Adesnik H, Iwanaga T, et al. (2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.". Science 313 (5794): 1792–5. doi:10.1126/science.1129947. PMID 16990550. 
  • Chabrol E, Gourfinkel-An I, Scheffer IE, et al. (2007). "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy.". Epilepsy Res. 76 (1): 41–8. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454. 
  • Gödde NJ, D'Abaco GM, Paradiso L, Novak U (2007). "Differential coding potential of ADAM22 mRNAs.". Gene 403 (1-2): 80–8. doi:10.1016/j.gene.2007.07.033. PMID 17884303. 
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v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinase
Other