Acridone synthase

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In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + N-methylanthraniloyl-CoA $\rightleftharpoons$ 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO₂

Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.

[edit] References

IUBMB entry for 2.3.1.159
BRENDA references for 2.3.1.159 (Recommended.)
PubMed references for 2.3.1.159
PubMed Central references for 2.3.1.159
Google Scholar references for 2.3.1.159
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Maier W, Baumert A, Schumann B, Furukawa H and Groger D (1993). "Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures". Phytochemistry 32: 691–698.
Matern U (1999). "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS. Lett. 448: 135–40. PMID 10217426.
Junghanns KT, Kneusel RE, Groger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta graveolens". Phytochemistry. 49: 403–11. PMID 9747538.