Talk:Aciclovir

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Good page. One small point about the mechanism that is a little biochemically inaccurate - the Aciclo-GTP form is an inhibitor because it is incorporated into nascent DNA resulting in chain termination. While the residue incorporated will be the GMP form, it is the GTP form that will be the substrate for the reaction (to drive it forward through pyrophosphate release). Cheers! --163.1.176.254 12:40, 30 April 2007 (UTC)

Great page, guys. Can we move it to the INN aciclovir and have acyclovir redirect there?

Consider it done. JFW | T@lk 20:32, 21 Dec 2004 (UTC)

Drugs of this class are also used in research as a method of ablating a specific cell type. viral thymidine kinase is transfected into the cell with a tissue specific promotor. It is therefore only expressed in that specific tissue. If acyclovir is then given those cells are selectively killed. Its an alternative to a gene knockout strategy. I'll try to research it and make the edit, no time now though. Povmcdov 21:29, 5 February 2007 (UTC)

Hi – I think you have the incorrect structure for this molecule. It appears that you have misplaced the double bond in the 6 membered ring on the guanosine base. You have it going from the 1 nitrogen to the 2 carbon, but I believe that it should go from the 2 carbon to the 3 nitrogen. Otherwise, thanks for the article. —Preceding unsigned comment added by 129.22.124.84 (talk) 22:47, August 24, 2007 (UTC)

[edit] Nees a structure image

Needs a proper structure representation rather than just a 3D image--ChemSpiderMan (talk) 17:41, 26 January 2008 (UTC)

The image was removed by someone who probably thought "aciclovir" was a misspelling :P Fvasconcellos (t·c) 22:11, 26 January 2008 (UTC)

[edit] Wrong tautomer?

The tautomer depicted in the figures of this article is different from the one listed by CAS. Which one is wrong? --Itub (talk) 14:52, 12 February 2008 (UTC)