Acetyl-CoA C-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction

2 acetyl-CoA $\rightleftharpoons$ CoA + acetoacetyl-CoA

Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes 1DLU, 1DLV, 1DM3, 1M1O, 1M1T, 1M3K, 1M3Z, 1M4S, 1M4T, 1NL7, 1OU6, 1QFL, 1WL4, 1WL5, 2F2S, 2IB7, 2IB8, 2IB9, 2IBU, 2IBW, and 2IBY.

[edit] References

IUBMB entry for 2.3.1.9
BRENDA references for 2.3.1.9 (Recommended.)
PubMed references for 2.3.1.9
PubMed Central references for 2.3.1.9
Google Scholar references for 2.3.1.9
LYNEN F, OCHOA S (1953). "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta. 12: 299–314. PMID 13115439.
Stern JR, Drummond GI, Coon MJ and del Campillo A (1960). "Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver". J. Biol. Chem. 235: 313–317.