8-oxocoformycin reductase

From Wikipedia, the free encyclopedia

In enzymology, a 8-oxocoformycin reductase (EC 1.1.1.235) is an enzyme that catalyzes the chemical reaction

coformycin + NADP⁺ 8-oxocoformycin + NADPH + H⁺

Thus, the two substrates of this enzyme are coformycin and NADP⁺, whereas its 3 products are 8-oxocoformycin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is coformycin:NADP+ 8-oxidoreductase. This enzyme is also called 8-ketodeoxycoformycin reductase.

[edit] References

• IUBMB entry for 1.1.1.235
• BRENDA references for 1.1.1.235 (Recommended.)
• PubMed references for 1.1.1.235
• PubMed Central references for 1.1.1.235
• Google Scholar references for 1.1.1.235
• Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ (1988). "8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin". Biochemistry. 27: 5790–5. doi:10.1021/bi00415a059. PMID 3052586. 

[edit] External links

The CAS registry number for this enzyme class is 114995-16-3.

• IUBMB entry for 1.1.1.235

• KEGG entry for 1.1.1.235

• BRENDA entry for 1.1.1.235

• NiceZyme view of 1.1.1.235

• EC2PDB: PDB structures for 1.1.1.235

• PRIAM entry for 1.1.1.235

• PUMA2 entry for 1.1.1.235

• IntEnz: Integrated Enzyme entry for 1.1.1.235

• MetaCyc entry for 1.1.1.235

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047599: 8-oxocoformycin reductase

• AMIGO entry for GO code 0047599: 8-oxocoformycin reductase