7beta-hydroxysteroid dehydrogenase (NADP+)

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In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.201) is an enzyme that catalyzes the chemical reaction

a 7beta-hydroxysteroid + NADP⁺ $\rightleftharpoons$ a 7-oxosteroid + NADPH + H⁺

Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP⁺, whereas its 3 products are 7-oxosteroid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP+ 7-oxidoreductase. Other names in common use include NADP+-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP+).

[edit] References

IUBMB entry for 1.1.1.201
BRENDA references for 1.1.1.201 (Recommended.)
PubMed references for 1.1.1.201
PubMed Central references for 1.1.1.201
Google Scholar references for 1.1.1.201
Hirano S, Masuda N (1982). "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens". Appl. Environ. Microbiol. 43: 1057–63. PMID 6954878.
MacDonald IA, Roach PD (1981). "Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum". Biochim. Biophys. Acta. 665: 262–9. PMID 6945134.
MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV (1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms". Appl. Environ. Microbiol. 44: 1187–95. PMID 6758698.