5-Lipoxygenase activating protein

From Wikipedia, the free encyclopedia

arachidonate 5-lipoxygenase-activating protein
Identifiers
Symbol	ALOX5AP
Entrez	241
HUGO	436
OMIM	603700
RefSeq	NM_001629
UniProt	P20292
Other data
Locus	Chr. 13 q12

5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes.^[1] It is bound to the nuclear membrane.

[edit] Pathology

Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease.^[2]

[edit] References

1. ^ Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins Leukot Essent Fatty Acids 69 (2-3): 99–109. doi:10.1016/S0952-3278(03)00070-X. PMID 12895592. 
2. ^ Manev H, Manev R (2006). "5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease". Med Hypotheses 66 (3): 501–3. doi:10.1016/j.mehy.2005.09.031. PMID 16278051. 

[edit] External links

• MeSH 5-lipoxygenase-activating+protein

v • d • e Metabolism: lipid metabolism - eicosanoid metabolism enzymes Prostanoids Cyclooxygenase - Thromboxane-A synthase - Prostacyclin synthase - Prostaglandin E synthase - Prostaglandin D2 synthase Leukotrienes Arachidonate 5-lipoxygenase - 5-Lipoxygenase activating protein - Leukotriene A4 hydrolase - Leukotriene C4 synthase