4-hydroxybutyrate dehydrogenase

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In enzymology, a 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybutanoate + NAD⁺ succinate semialdehyde + NADH + H⁺

The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD⁺, whereas its 3 products are succinate semialdehyde, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.^[1] The systematic name of this enzyme class is 4-hydroxybutanoate:NAD+ oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid.^[2]

[edit] References

• IUBMB entry for 1.1.1.61
• BRENDA references for 1.1.1.61 (Recommended.)
• PubMed references for 1.1.1.61
• PubMed Central references for 1.1.1.61
• Google Scholar references for 1.1.1.61

[edit] External links

• IUBMB entry for 1.1.1.61

• KEGG entry for 1.1.1.61

• BRENDA entry for 1.1.1.61

• NiceZyme view of 1.1.1.61

• EC2PDB: PDB structures for 1.1.1.61

• PRIAM entry for 1.1.1.61

• PUMA2 entry for 1.1.1.61

• IntEnz: Integrated Enzyme entry for 1.1.1.61

• MetaCyc entry for 1.1.1.61

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047577: 4-hydroxybutyrate dehydrogenase

• AMIGO entry for GO code 0047577: 4-hydroxybutyrate dehydrogenase