4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

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In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.45) is an enzyme that catalyzes the chemical reaction

4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP⁺ + H₂O 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP⁺, and H₂O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

[edit] References

• IUBMB entry for 1.2.1.45
• BRENDA references for 1.2.1.45 (Recommended.)
• PubMed references for 1.2.1.45
• PubMed Central references for 1.2.1.45
• Google Scholar references for 1.2.1.45
• Maruyama K, Ariga N, Tsuda M, Deguchi K (Tokyo). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". J. Biochem.: 1125–34. PMID 26671. 

[edit] External links

The CAS registry number for this enzyme class is 67272-39-3.

• IUBMB entry for 1.2.1.45

• KEGG entry for 1.2.1.45

• BRENDA entry for 1.2.1.45

• NiceZyme view of 1.2.1.45

• EC2PDB: PDB structures for 1.2.1.45

• PRIAM entry for 1.2.1.45

• PUMA2 entry for 1.2.1.45

• IntEnz: Integrated Enzyme entry for 1.2.1.45

• MetaCyc entry for 1.2.1.45

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050606: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

• AMIGO entry for GO code 0050606: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase